Winger Josh Drauniniu also returns to the side in place of the injured Dean Hammond whilst the rest of the starting line-up remains unchanged from the narrow defeat at Harlequins in Round 16.
Mike Williams keeps his place in the back-row next to Sam Betty and Jonathan Thomas, whilst James Percival and Mariano Galarza occupy the second-row.
Jonny Arr starts at scrum-half whilst Ryan Lamb keeps his place at stand-off alongside Ravai Fatiaki and Alex Grove in the centre. David Lemi starts on the left wing with Chris Pennell at full-back.
Andy Symons is named in the replacements and could be in line to make his first Warriors appearance since December after being sidelined with a shoulder injury.
Richard de Carpentier and Ignacio Mieres are also recalled to the squad for the crucial encounter.
Director of Rugby Dean Ryan said: "We know we stare at relegation if we can't win at Newcastle and winning against Wasps is the key to being successful at Kingston Park.
"Relegation has sat heavy over the club since losing to London Irish and Newcastle at home early in the season. The stakes are that high.
"Ryan Lamb coming in has given a bit of direction and a bit of freshness to the squad.
"Some guys have also grown in confidence because they're part of the picture going forward and there has been a response from them. Those sorts of things have allowed us to stay reasonably buoyant.
"I don't think the winning a game pressure is an issue. It's the magnitude of not winning the game which is the suffocating pressure.
"The most important focus for us now isn't that we are running out of time and games.
"It's that pure focus of winning at Kingston Park which will be easier if we can get a win under our belts this Friday."
15 Chris Pennell
14 Josh Drauniniu
13 Alex Grove
12 Ravai Fatiaki
11 David Lemi
10 Ryan Lamb
9 Jonny Arr
1 Ofa Fainga'anuku
2 Agustin Creevy
3 Euan Murray
4 James Percival
5 Mariano Galarza
6 Mike Williams
7 Sam Betty
8 Jonathan Thomas (C)
16 Ed Shervington
17 Paul Andrew
18 Rob O'Donnell
19 Semisi Taulava
20 Richard de Carpentier
21 Paul Hodgson
22 Ignacio Mieres
23 Andy Symons