But the giant forward will return against Leicester in the front-row as Dean Ryan makes six changes to the side that faced Exeter Chiefs in the LV= Cup last weekend.
Creevy will be joined by Ofa Fainga'anuku and John Andress in the front-row, while James Percival and Mariano Galarza will feature at second-row.
Mike Williams keeps his place in the back-row alongside Sam Betty and captain Jonathan Thomas.
Jonny Arr returns at scrum-half and Paul Warwick replaces Ignacio Mieres as stand-off.
Alex Grove, who was on Scotland A duty against England Saxons last weekend, returns to the side in place of youngster Max Stelling at outside-centre.
David Lemi will start his first Premiership game since November with Josh Drauniniu on the opposite wing.
Leonardo Senatore, Paul Hodgson and Josh Matavesi are all named in the replacements.
Ryan said: "Leicester must be delighted that Toby Flood and Ben Youngs are available and that Anthony Allen is back.
"They've got a significant injury list but they have a significant squad. That's what a good club is. It has layers of depth and a heritage of success.
"That's what we are trying to build and Leicester are a great template for success over the years.
"People only go there that want to be successful and they are a great Premiership advert for English rugby.
"They're always very physical and they've always got great set-piece. They've got some world-class players in that team.
"I'm desperate for this club to fight for its survival and therefore I've got to frame decisions around that.
"We're going to have to beat a team like Leicester, Northampton or Harlequins if we are to get ourselves out of this position.
"That starts at home this Friday night and we will fight like mad to give ourselves every chance."
15 Chris Pennell
14 Josh Drauniniu
13 Alex Grove
12 Ravai Fatiaki
11 David Lemi
10 Paul Warwick
9 Jonny Arr
1 Ofa Fainga'anuku
2 Agustin Creevy
3 John Andress
4 James Percival
5 Mariano Galarza
6 Mike Williams
7 Sam Betty
8 Jonathan Thomas (C)
16 Ed Shervington
17 George Porter
18 Rob O'Donnell
19 Dean Schofield
20 Leonardo Senatore
21 Paul Hodgson
22 Ignacio Mieres
23 Josh Matavesi