Fellow academy youngsters Ben Howard and Max Stelling will both feature in the side after signing first-team contracts for next season earlier this week.
Josh Matavesi and Jonny Arr, who both came on as replacements last weekend, return to the starting line-up after spells on the sidelines with injury.
The forward pack sees a reshuffle with Jeremy Becasseau, Ed Shervington and John Andress named in the front-row.
Dean Schofield, who will captain the side, is recalled to the second-row alongside Mike Williams, while Chris Jones is given a starting berth in the back-row.
Warriors name a strong bench with Aviva Premiership regulars Rob O'Donnell, James Percival, Sam Betty, Ignacio Mieres and Ravai Fatiaki amongst the replacements.
Ryan said: "The Amlin is an opportunity for some of the youngsters to get involved. We've done that right from the first game and we will do that again over this period.
"We'll look to utilise these guys again over the next three or four weeks to see if they have grown from their experiences.
"Sometimes growing youngsters can be difficult because sometimes they get thrust in and it's difficult to learn, especially in an environment that isn't as successful as we would like it to be.
"It's important that youngsters get space to come out and play and then they can reflect on their performances before coming back in. We have been able to do that across the competitions this season.
"The reason we have chopped and changed with selection is because nobody has really nailed down a position so that means they are still up for grabs.
"That allows some of those that have been on the fringes to have a go to try and put their hand up."
Sale Sharks vs Worcester Warriors
15 Ben Howard
14 Josh Drauniniu
13 Max Stelling
12 Josh Matavesi
11 Josh Watkins
10 Paul Warwick
9 Jonny Arr
1 Jeremy Becasseau
2 Ed Shervington
3 John Andress
4 Dean Schofield (C)
5 Mike Williams
6 Chris Jones
7 Richard de Carpentier
8 Leonardo Senatore
16 Nick Seymour
17 George Porter
18 Rob O'Donnell
19 James Percival
20 Sam Betty
21 Paul Hodgson
22 Ignacio Mieres
23 Ravai Fatiaki