Scotland international prop Euan Murray makes his first appearance for Warriors at Sixways as he comes into the front row with John Andress among the replacements.
Head Coach Hill admitted the game was crucial to Worcester's hopes of progressing in Europe this season and he expects an exciting game in front of the television cameras.
"It is a really exciting game and on the back of two very good league performances we are in a positive frame of mind," he said.
"We are desperate to get into the quarter-finals and we are top of the group at the moment. But we know we have a really tough task against a powerful French team.
"They have a quick turnaround as they travel over on Wednesday and play Thursday night so we have got to hit them with everything we can in this first game. If we can get a win in this one, it puts us in a strong position for the second game the following week."
Tickets remain on sale for the European clash at Sixways. Call the Warriors Box Office on 01905 454183 or click HERE to buy tickets online.
Warriors vs. USA Perpignan
15 Chris Pennell
14 Nikki Walker
13 Alex Grove
12 Josh Matavesi
11 David Lemi
10 Andy Goode
9 Paul Hodgson
1 Ceri Jones
2 Ed Shervington
3 Euan Murray
4 James Percival (c)
5 Chris Jones
6 Neil Best
7 Matt Kvesic
8 Semisi Taulava
Replacements
16 Aleki Lutui
17 Rob O'Donnell
18 John Andress
19 Dean Schofield
20 Sam Betty
21 Jonny Arr
22 Errie Claassens
23 Andy Short




