Making up the other pool are Gloucester Rugby, who progressed as Group A runners-up on home soil last Thursday, Saracens and 2011 J.P. Morgan Premiership Rugby 7s champions Newcastle Falcons.
The Warriors have faced the Aviva Premiership Rugby champions just once before in the competition and picked up a 19-12 win - their only previous 7s victory prior to their three scalps at Kingsholm.
And with captain Richard De Carpentier poised to lead Dean Ryan's side out against his old club Leicester the 23-year-old admits he is relishing the opportunity to start the evening with a victory.
"It will be great to start things off, hopefully they can pack The Rec out and it should be an exciting night," he added.
"I get on with a lot of the boys at Leicester well and it will be good to see a few friendly faces again.
"They didn't have a great history in the tournament either as they usually take a lot of younger lads but we will see what team they bring on Friday and hopefully we can both be competitive.
We had a look back at Thursday and we were all pretty happy with the way that we defended in most games and the way we came out of the blocks and started scoring tries early doors.
"We were saying to the boys before the match 'don't be afraid to show what you can do' and we want them to do the same on Friday."
Similarly Leicester 7s captain Scott Steele will be looking to secure a win to put the Tigers in a strong position first up and having witnessed the Warriors progress with ease on Thursday he admits the opening fixture will be a tough clash.
"The Worcester squad is really good and having watched them I was really impressed so it will be great to open the tournament and start with a win," said Steele.
"I just want more of the same for us and if we go out there, and play with a bit of freedom, we might be able to get a few wins but let's see how it goes.
"It just shows you that 7s is a game where any team can beat anyone in a short space of time and they do have good players and had a similarly bad record like us.
They have a new coaching staff and are high in confidence so it will be a tough game to start.
"We were a little bit surprised to get through with the young squad that we had but it just shows us that if we work hard we know we can beat teams and hopefully we can go on and beat a few more on Friday."
Full Fixture List for Friday night:
Game 1 (7pm): Worcester Warriors v Leicester Tigers
Game 2: Gloucester Rugby v Newcastle Falcons
Game 3: Leicester Tigers v Harlequins
Game 4: Newcastle Falcons v Saracens
Game 5: Worcester Warriors v Harlequins
Game 6: Gloucester Rugby v Saracens