The clash against Biarritz, five times French champions and winners of the Amlin Challenge Cup in 2012, is sure to create huge interest with Worcester having never faced the French giants before.
Biarritz, who are also twice runners-up in the Heineken Cup, currently boast a squad that contains the likes of Dimitri Yachvili and captain Imanol Harinordoquy.
Warriors also face Sale Sharks and Oyonnax, champions of Pro D2 this season who have then been promoted to the French top-flight.
Full details of all fixtures will be released when agreed by all clubs.
Amlin Challenge Cup 2013/14 Pools:
Pool 1: Biarritz Olympique PB, Sale Sharks, Worcester Warriors, Oyonnax
Pool 2: Bath Rugby, Newport Gwent Dragons, Bordeaux-Bègles, Mogliano Rugby
Pool 3: Brive, Newcastle Falcons, Cammi Rugby Calvisano, Bucharest Wolves
Pool 4: London Wasps, Rugby Viadana, Bayonne, Grenoble
Pool 5: Stade Français Paris, London Irish, I Cavalieri Prato, Olympus Rugby XV