Scotland Head Coach Scott Johnson has also named three new caps for the match as 24-year-old Edinburgh Rugby full-back Greig Tonks and Glasgow Warriors duo Alex Dunbar, 23, and Pat MacArthur, 26, make their debuts.
In addition there are a further three uncapped players on the bench - Stevie Lawrie, Peter Horne and Duncan Taylor - while two players in the starting line-up have won a solitary cap each - Bath Rugby's Tom Heathcote at stand-off and Grant Gilchrist (Edinburgh Rugby) at lock.
All in, there are five changes of personnel and one positional switch from Scotland's last game - the narrow defeat away to France, which rounded-off the RBS Six Nations Championship in March.
And there are eight survivors from the starting line-up that defeated Samoa in the sweltering heat of Apia last June.
Johnson ranked Scotland's win in Samoa last year as a tremendous achievement and expects a fierce encounter this weekend.
He said: "We want to broaden the base and it gives us the perfect opportunity to see how these guys stand up in Test footy."
Scotland team to play Samoa; Kick-off 1.15pm BST
15 Greig Tonks (Edinburgh Rugby) uncapped
14 Sean Lamont (Glasgow Warriors) 76 caps, 9 tries, 45 points
13 Alex Dunbar (Glasgow Warriors) uncapped
12 Matt Scott (Edinburgh Rugby) 12 caps, 1 try, 5 points
11 Tim Visser (Edinburgh Rugby) 10 caps, 6 tries, 30 points
10 Tom Heathcote (Bath Rugby) 1 cap
9 Greig Laidlaw (Edinburgh Rugby) 18 caps, 2 tries, 16 conversions, 39 penalties, 159 points
1 Ryan Grant (Glasgow Warriors) 10 caps
2 Pat MacArthur (Glasgow Warriors) uncapped
3 Euan Murray (Worcester Warriors) 53 caps, 2 tries, 10 points
4 Grant Gilchrist (Edinburgh Rugby) 1 cap
5 Alastair Kellock (Glasgow Warriors) 52 caps, 1 try, 5 points
6 Alasdair Strokosch (Perpignan) 32 caps, 1 try, 5 points
7 Kelly Brown (Saracens) CAPTAIN 57 caps, 4 tries, 20 points
8 Johnnie Beattie (Montpellier) 21 caps, 3 tries, 15 points
16 Stevie Lawrie (Edinburgh Rugby) uncapped
17 Alasdair Dickinson (Sale Sharks) 24 caps, 1 try, 5 points
18 Geoff Cross (Edinburgh Rugby) 21 caps, 1 try, 5 points
19 Jim Hamilton (Gloucester) 46 caps, 1 try, 5 points
20 Ryan Wilson (Glasgow Warriors) 2 caps
21 Henry Pyrgos (Glasgow Warriors) 6 caps, 1 try, 5 points
22 Peter Horne (Glasgow Warriors) uncapped
23 Duncan Taylor (Saracens) uncapped.