He said: "Tomorrow's game is a good chance for us to put a good performance in. If we can look after the ball and stay disciplined, we've got a good chance to win the game.
"We've been preparing ourselves with a lot of fitness and it's been a good build-up. We've had contact sessions and we're up for it."
Warriors swept to a 35-11 win over Irish at Sixways back in September to secure their maiden victory of the campaign.
That game was Clarke's first in a Warriors shirt and he went on to score his side's fourth try in a man-of-the-match performance.
And the former Heineken Cup finalist says there is no reason the players can't reach those heights again.
He continued: "We played very well against them on our own patch and I can't see why we can't match that tomorrow.
"We've got to take our performance from the Wasps game into the Irish game and we need to keep moving forward."
Warriors have already faced Irish at the Madejski Stadium this season as they were defeated in the LV= Cup.
And Clarke admits his side must balance their defence and attack if they are to be successful this time around.
He added: "We have to defend our hearts out because they've got some very good runners. But we have to have that confidence to attack as well. We know we have to get the ball in hand, look after it and aim for the tries.
"Another win would be great. It would set us up for the Exeter game, put pressure on the teams above us and give us momentum."