Director of Rugby Mike Ruddock has named the same starting line-up that recorded a 19-13 victory over Plymouth Albion last Saturday.
"We have selected a very strong team for the first game of the campaign at Sixways," said Ruddock.
"Clive Griffiths, Billy McGinty and myself have been really pleased with the way the players have worked on their skills and conditioning during the summer.
"Hopefully we can transfer the good work from training to a game situation against a very good outfit."
Worcester Warriors team to face London Irish:
01 Tony Windo, 02 Chris Fortey, 03 Tevita Taumoepeau, 04 Phil Murphy, 05 Craig Gillies, 06 Tom Wood, 07 Pat Sanderson (c), 08 Gavin Quinnell, 09 Matt Powell, 10 Shane Drahm, 11 Marcel Garvey, 12 Gary Trueman, 13 Dale Rasmussen, 14 Thinus Delport, 15 Chris Pennell
Replacements: 16 Darren Morris, 17 Ben Gotting, 18 Will Bowley, 19 Drew Hickey, 20 Ryan Powell, 21 Joe Carlisle, 22 Mark Tucker