Craig Gillies will be joined by Phil Murphy in the second row with Tony Windo handed a starting shirt in the front row alongside Chris Fortey and Tevita Taumoepeau.
Rising star Chris Pennell is named at full back after grabbing four tries at Twickenham and Marcel Garvey will be looking to add to his try haul after a stunning display at the home of English rugby.
Worcester will be without all of their six summer signings. Samoan international Loki Crichton and Fijian Netani Talei are away on World Cup duty while Sam Tuitupou, Rico Gear and Greg Rawlinson will not join Warriors until later in the year. Shaun Ruwers is unavailable for selection.
Worcester Warriors team to face Plymouth Albion:
01 Tony Windo, 02 Chris Fortey, 03 Tevita Taumoepeau, 04 Phil Murphy, 05 Craig Gillies, 06 Tom Wood, 07 Pat Sanderson (c), 08 Gavin Quinnell, 09 Matt Powell, 10 Shane Drahm, 11 Thinus Delport, 12 Gary Trueman, 13 Dale Rasmussen, 14 Marcel Garvey, 15 Chris Pennell
Replacements: 16 Ben Gotting, 17 Darren Morris, 18 Will Bowley, 19 James Collins, 20 Ryan Powell, 21 Joe Carlisle, 22 Mark Tucker