Warriors have claimed crucial wins over Bath Rugby, Sale Sharks and Newcastle Falcons in a thrilling month as they climbed off the foot of the table.
Brain's work to mastermind the March charge has now been rewarded on the eve of the trip to Bristol with a top award.
However, the Worcester boss remains clearly focussed on the task in hand and keeping Warriors in the top-flight.
"Whilst I'm pleased to win this individual award, I see it as reconginition for all the hard work put in by both players and staff in starting to turn our season around. However, we all know that we still have a lot of work to do.
When asked about the prospect of relegation, Brain remains very optimistic about Guinness Premiership rugby at Sixways next season.
"We have not spent a lot of time contemplating relegation," he said. "I have not once sat down and thought for any prolonged period about life in National League One. I have always felt that we have got the capacity to get ourselves out of it and I still very much believe that."
The voting panel consisted of five members of the rugby media and the PRA representative from each of the 12 Guinness Premiership clubs.
And speaking of Brain's Guinness Premiership Director of the Month award, voting panel chairman, Sky's Miles Harrison, said: "It is not very often that a boss towards the lower reaches of the table wins an award like this but he has overseen a dramatic turn in his club's fortunes during March in the Guinness Premiership.
"Although John fully knows that his work this season is far from done, his achievements over the last few weeks attracted almost unanimous support from the voting panel."