Tim Collier replaces Phil Murphy in the second row, where he will play alongside Craig Gillies who is set to start his 100th Premiership game.
Tongan prop Tevita Taumoepeau starts in the front row in place of Wales international Chris Horsman who drops to the bench after his Six Nations exploits.
Lock Richard Blaze, who has been out of action since the autumn, returns on the replacements bench after a successful comeback for the Warriors Development XV at Sale.
Worcester Warriors team to face Leicester Tigers:
01 Darren Morris, 02 Chris Fortey, 03 Tevita Taumoepeau, 04 Craig Gillies, 05 Tim Collier, 06 Drew Hickey, 07 Pat Sanderson (c), 08 Kai Horstmann, 09 Ryan Powell, 10 James Brown, 11 Marcel Garvey, 12 Gary Trueman, 13 Dale Rasmussen, 14 Aisea Havili, 15 Shane Drahm
Replacements: 16 Chris Horsman, 17 Aleki Lutui, 18 Richard Blaze, 19 Tom Harding, 20 Nick Runciman, 21 Dominic Feaunati, 22 Thinus Delport