France are the opponents on March 13 with the tournament completed by the visit of Scotland on March 20 and both these games will be shown live on SkySports.
England Under 20 coach Mark Mapletoft said: "We're delighted to be playing our home games at Worcester this season and we hope rugby fans will turn out in force to watch us.
"The recent developments at Sixways make it a magnificent stadium to visit where the crowd generates a fantastic atmosphere to play in.
"Worcester fans will know that Miles Benjamin and Matt Cox were two of the players who helped England make such an impact at this level last season and now the challenge is for the next group of young international players to follow in their footsteps.
"It's an exciting time to be working with young players of the quality we have in England and I'm sure spectators at our games will enjoy the athletic and attractive brand of rugby we aspire to play."
England completed a clean sweep of Six Nations victories in 2008 before reaching the final of the IRB Junior World Championship in June. In all they won nine out of 10 games and scored 41 tries in the process.
Worcester Warriors General Manager Charlie Little said: "It is a great honour and privilege for Worcester Warriors to be hosting England this season as the team looks to successfully defend its RBS Under 20 Six Nations crown.
"We believe our club is a perfect place for young talent to develop. We have one of the largest mini/junior sections in our amateur club as well as the thriving Academy section which has produced players like Miles Benjamin, Matt Cox, Jonny Arr and Greg King who have all represented England at this level.
"Hosting these games underlines the work we are undertaking with the next generation of rugby stars and this season we are delighted that Graham Kitchener is in the England Under 20 set-up and wish him all the best on home soil playing for his country.
"This is also recognition for the recent development of Sixways Stadium and our facilities. With the new Slick Systems Stand our capacity is now over 12,000 and we would encourage fans to support all three games and the England squad."
Kitchener, 19, made his England Under 20 debut as a replacement against Scotland last season and started the 41-13 Grand Slam clinching victory against Ireland. He made his first team debut for the Warriors against Bath last month.
England's other RBS Under 20 Six Nations fixtures see them travel to face Wales in Bridgend on February 13 before taking on Ireland in Athlone on February 27.
The Six Nations is followed by the IRB Junior World Championship in Japan next June.
Ticketing details for the games at Sixways Stadium will be announced first at www.warriors.co.uk
England Under 20 fixtures
February 6: England U20 v Italy U20 (Worcester, 8pm)
February 13: Wales U20 v England U20 (Bridgend)
February 27: Ireland U20 v England U20 (Athlone)
March 13: England U20 v France U20 (Worcester, 8pm) Live on SkySports
March 20: England U20 v Scotland (Worcester, 8pm) Live on SkySports