Tim Molenaar, who has enjoyed such an impressive first season with Gloucester, resumes his partnership in the centre in Tindall's absence with Eliota Fuimaono-Sapolu.
Meanwhile, on a weekend where so many Gloucester players are on international duty, Rory Lawson is a welcome returnee from the Scotland camp.
In the pack, Pierre Capdevielle comes in for Paul Doran-Jones who picked up a knee injury in Cardiff and Adam Eustace replaces Jake Boer who also left the Welsh capital with an injury.
Head Coach Bryan Redpath said: "It's massive for the club. We set ourselves some targets to achieve and the first of those comes up with this final on Sunday."
"Your next game is your biggest challenge and last week is gone and we've learned from that. You move on and this is a big game for us."
"Northampton are a quality side. They've been very consistent throughout the season. We've looked at some of the stuff they've achieved this season and admired it. It's been outstanding."
"It's going to be a tough challenge, we have a fairly hefty injury and absentee list. But that's life. The boys that are here are still good enough to go out and compete at this level. I'm happy with the boys that are around."
Tickets are still available for the match between the Saints and Gloucester. Prices cost £20 or £25 for adults and just £10 for juniors throughout the stadium. Supporters can order online from the Warriors website today (Friday) and Saturday for collection on Sunday, and on the match day itself in person at the Warriors Box Office.
Freddie Burns; James Simpson-Daniel, Tim Molenaar, Eliota Fuimaono-Sapolu, Lesley Vainikolo; Nicky Robinson, Rory Lawson; Nick Wood, Olivier Azam, Pierre Capdevielle; Will James, Alex Brown; Peter Buxton (capt), Akapusi Qera, Adam Eustace
Darren Dawidiuk, Yann Thomas, Rupert Harden, Apo Satala, Andy Hazell, Dave Lewis, Tom Voyce, Charlie Sharples