Director of Rugby Mike Ruddock has revealed that star trio Matt Mullan, Miles Benjamin and Chris Pennell are all set for an enforced spell on the sidelines.
Prop Mullan and wing Benjamin are both set for shoulder surgery that will end any further competitive action for Warriors this season.
Wing Pennell is also set to miss the Guinness Premiership home clashes with London Irish and London Wasps with a fractured jaw, but could return for the crunch away clash at Leeds Carnegie later this month.
However, Ruddock insists his squad has the depth and quality to cope with the absences in the league run-in.
"Matt Mullan will miss the rest of this season with a shoulder operation. Miles Benjamin will also miss the rest of the campaign as he also needs shoulder surgery," he said.
"Miles failed a fitness test after the Leicester Tigers game and he now needs surgical intervention.
"Chris Pennell is going to be out for a couple of weeks after he fractured his jaw against Sale. It is not a serious or complicated fracture, but it could put him out for three weeks so with a bit of luck he will make the Leeds game.
"This is a huge collision based sport and there are massive collisions out there. There is no team in the league that is going to go through the season without people being operated on or missing games for long periods, that is why you try and develop a squad.
"We are very lucky in those areas because we have Adam Black playing really well at loosehead and also Callum Black. We have good guys stepping in.
"Miles Benjamin drops out but it gives us the chance to look at Marcel Garvey and Rico Gear with Chris Pennell also out. When you look at the quality there is no reason why we can't play to a high level."
Worcester Warriors' long-term vision to become an established Aviva Premiership Club has been given a significant boost after concluding an agreement with Worcester Rugby, the group that runs amateur club Worcester Wanderers Rugby Club, over the usage of the whole of the Sixways Stadium site.