Perry Freshwater (Perpignan) will win his fourth cap when he replaces Andrew Sheridan (Sale Sharks) at loose-head against the Pumas.
On the replacement bench, Tom Palmer (London Wasps) takes over from Chris Jones (Sale Sharks), while Toby Flood (Newcastle Falcons) and Josh Lewsey (London Wasps) come in for Andy Goode (Leicester Tigers) and Mark Van Gisbergen (London Wasps).
Martin Corry captains the side with Shaun Perry, Charlie Hodgson and Ben Kay as vice-captains.
Team: 01 Perry Freshwater (Perpignan), 02 George Chuter (Leicester), 03 Julian White (Leicester), 04 Danny Grewcock (Bath), 05 Ben Kay (Leicester), 06 Martin Corry (Leicester) (c), 07 Lewis Moody (Leicester), 08 Pat Sanderson (Worcester), 09 Shaun Perry (Bristol), 10 Charlie Hodgson (Sale), 11 Ben Cohen (Northampton), 12 Anthony Allen (Gloucester), 13 Jamie Noon (Newcastle), 14 Paul Sackey (Wasps), 15 Iain Balshaw (Gloucester)
Replacements: 16 Lee Mears (Bath), 17 Stuart Turner (Sale), 18 Tom Palmer (Wasps), 19 Magnus Lund (Sale), 20 Pete Richards (Gloucester) 21 Toby Flood (Newcastle), 22 Josh Lewsey (Wasps)