Director of Rugby Philippe Saint Andre said: "It was a bad injury and he has had surgery to repair the damage. It shows how much Jason is a team man in that he played for 75 minutes in pain but refused to be replaced. We will miss him but on the plus side Chris Jones takes his place after making his comeback in the Boxing Day win.
"I have rotated Richard Wigglesworth and Dwayne Peel at Scrum Half. Mathew Tait is a lot better following his illness over Christmas, but is not ready to play a part this weekend.
"The game at Worcester is a massive game for us in that we have been playing well and need to keep in touch with the Premiership leaders. Next week we entertain London Irish at Edgeley Park and this too will be a huge game for us. The spirit amongst the squad is first class and everyone wants to play a part."
Sale Sharks: Mark Cueto, Chris Bell, Andy Tuilagi, Luke McAlister, David Doherty, Charlie Hodgson, Dwayne Peel, Lionel Faure, Marc Jones, Eifion Roberts, Sebastien Chabal, Dean Schofield, Chris Jones, Neil Briggs, JM Fernandez Lobbe (c)
Replacements: Stuart Turner, Andrew Sheridan, Brent Cockbain, Carl Fearns, Richard Wigglesworth, Nick McLeod, Oriol Ripol