A last gasp penalty from Loki Crichton earned Worcester a first league win last season at Adams Park and the Sixways side followed it up with victory a one-point thriller in the home fixture.
Warriors have lost just once to Wasps in the last five outings, but will face a home side who sit top of the Guinness Premiership going into the weekend and who have won their last nine games at Adams Park in all competitions.
"We go back to Wasps a year after we snuck a win with the last kick of the game and it would be nice if we could go back and do that again," said Ruddock.
"Wasps are always a difficult team to face. They have a very strong squad with a lot of experience. It will be a big ask for us and you can see why they have started so well, even though they are without people like Simon Shaw after the Lions tour.
"We beat them twice last season and we're expecting a very tough test. I would expect they will be after some revenge and they won't want to lose to us again on their home patch.
"It will be a very robust and physical encounter, we have got to get there and tackle hard and make life difficult for them and take our chances when they come along."
Director of Rugby Ruddock has been happy with the form his side had shown so far this season - and praised his forwards who have impressed in the opening weeks.
"I think our breakdown work has been getting better - we were very good against Northampton and for 60 minutes against Leeds we were pretty good," he added.
"The scrum has been a very positive aspect of our performance - we dominated up front against Leeds. When Tevita Taumoepeau came off the bench against Northampton he was a little bit off the pace to start with after summer shoulder surgery, but he quickly came back and delivered in the heat of battle.
"Matt Mullan didn't have much match fitness going into the Saints game, but the scrum performed well.
"Our line-out has been working well too, with Craig Gillies stealing a lot of ball against Leeds. Our kicking game has been pretty good against Leeds, so overall I can only ask for a bit more continuity in our game."
Ruddock also travels to Wasps with no reports of fresh injury worries, expect for prop Shaun Ruwers after his outing at Franklins' Gardens at the start of the week.
He added: "Shaun picked up a bit of a knock and sore ribs in the A Leagur game against Northampton.
"Callum Black, though, has passed a fitness test so he is available for selection if we need him, if we are unfortunate enough to lose Shaun."
