Eves, 19, is one of five changes to the side beaten 19-18 in Ireland last month as England take the number of players named in four matchday squads to 36.
He is comfortably the most experienced player in the Under 20 squad after playing every minute of last year's Six Nations Grand Slam campaign and starting in four games at the 2008 IRB Junior World Championship.
"The experience Luke gained with us last season and in the first team with his club has been hugely beneficial to him and I'm very grateful that [Bristol's] Paul Hull has released him to play for us," said coach Mark Mapletoft.
"It's a big responsibility to captain your country at any level but I hope he enjoys it. If he plays with the same intensity he's trained with this week, I'm sure he will."
The back row is reshaped with Clark injured and Josh Ovens suspended, so Jamie Gibson (London Irish) and Jacob Rowan (Leeds Carnegie) will win their first caps at this level.
Both played for England's unbeaten Under 18 side last season, with Rowan going on to feature in the first team for Leeds while Gibson is completing A Levels in Latin, Greek and Mathematics at Marlborough College.
"The back row will be a very physical area of the game and it's a big ask of Jacob and Jamie but we wouldn't have selected them if we didn't feel they were up to the task," said Mapletoft.
"Both were outstanding in the Under 18 side last year and now they have a chance to push for places in this summer's Junior World Championship."
The other changes up front see lock Dan Williams return from Guinness Premiership duty with Gloucester and Bob Baker (London Wasps) restored at tighthead prop.
Eves starts at 13 so Athlone tryscorer George Lowe (Harlequins) moves to the wing in place of Will Hurrell.
On the bench, prop Joe Marler (Harlequins) returns to the squad after injury ruled him out of the opening three games.
Both sides on view at Worcester will be out to put pressure on Ireland, who top the Six Nations table after the first three rounds.
Ireland, who beat England and France by one and three points respectively, finish the championship with away games against Scotland in Perth and Wales at Llanelli.
England Under 20
15 Greig Tonks (Leicester Tigers)
14 Seb Stegmann (Harlequins)
13 Luke Eves (Bristol Rugby, captain)
12 Tom Casson (Saracens)
11 George Lowe (Harlequins)
10 Rory Clegg (Newcastle Falcons)
9 Dan White (Leeds Carnegie)
1 Ben Moon (Exeter Chiefs)
2 Jamie George (Saracens)
3 Bob Baker (London Wasps)
4 James Gaskell (Sale Sharks)
5 Dan Williams (Gloucester Rugby)
6 Jamie Gibson (London Irish)
7 Jacob Rowan (Leeds Carnegie)
8 Chris York (Harlequins)
16 Arthur Ellis (London Wasps)
17 Joe Marler (Harlequins)
18 Peter Elder (London Wasps)
19 Tom Sargeant (Harlequins)
20 Sam Harrison (Leicester Tigers)
21 Freddie Burns (Gloucester Rugby)
22 Will Hurrell (Leicester Tigers)
Tickets remain on sale for England U20s versus France U20s. Call the Warriors Box Office on 01905 454183 today for more information!