Warriors travel to the Madejski Stadium eager to return to winnings ways after narrow defeat to Northampton Saints last weekend.
Forwards coach Windo was a try scorer the last time Warriors tasted success in Reading in 2005 and he is confident the current crop can achieve the same aim if they can cut out the mistakes.
"It was a disappointing result for us last week and we were disappointed in ourselves," he said.
"We've looked at it and it has been a very positive week in training and the boys are upbeat. There are a few areas that we want to tighten up and what we have focused on is that we created a lot of chances. We made nine line breaks against Saints, they had less but took their chances.
"We have got to keep creating those chances and keep pushing to take them. However, we've got to stop making poor decisions in certain areas, knocking the ball on or losing the ball in contact.
"We are making the problems ourselves rather than the opposition making them for us. We've got to eradicate our errors and then we will be in a good position to move on."
London Irish are without a win in the Guinness Premiership since their 48-8 victory at home to Newcastle on 3 January.
But Windo has warned the Exiles are a dangerous and well organised side with plenty of talented players.
"Irish are a very well drilled side, one of the best in the league. It is going to be a tough afternoon but that is the league we are in," he said.
"They have had a tough run but they have played top sides and picked up bonus points every time, they are by no means in a bad patch, they have just been on the wrong side of some tight games.
"We went to Sale earlier in the season in the same situation. They were pushing high and may be took their eye of the game, we have to focus on ourselves."
Windo revealed that Warriors are set to make a change in the front row for the clash with big Tongan prop Tevita Taumoepeau injured.
"Tevita, unfortunately, has picked up a shoulder injury," added Windo. "The good news is that the neck injury that he has been carrying over the last few weeks has made good progress and he is over that.
"But he has been unlucky and with the nature of the game has taken a big impact on his shoulder and he will probably be out this week.
"Chris Horsman is seeing a specialist in Monday so we will know more about him from the early part of next week. We are hoping that we get some positive news from that and get him back in the fold soon.
"Alex Grove took a bang on the head but hopefully he will recover enough to get involved."
